AutoLAB-HPLC- A fast-response purification lab supporting medicinal chemistry inside a large pharmaceutical company
PROBLEM The purification lab was struggling to processes material quickly enough, staff was overwhelmed, and upper management wanted the lab to “do more with less” GOALS/SOLUTIONS The company’s lab manager needed to increase throughput, reduce lab size, and reduce staff. At first these collective goals seemed unachievable. After discussions with PDR-Separations the company decided to […]
AutoPREP-SD1- A Fast-response purification lab supporting medicinal chemistry inside a large pharmaceutical company
PROBLEM The lab was struggling to process material quickly enough using 2 mid-scale preparative HPLC purification systems. Each system included 3 200 mL/min SD1 pumps (2 for eluent mixing and 1 for injection). GOALS/SOLUTIONS The company’s lab manager needed to increase throughput and make systems easier to setup and use. After discussions with PDR-Separations the […]
AutoLAB-CCC- A fast-response purification lab supporting medicinal chemistry inside a large pharmaceutical company
PROBLEM The lab was struggling to process material quickly enough using CounterCurrent Chromatography (CCC) and the HPLC-centric staff was reluctant to use CCC. GOALS/SOLUTIONS The company’s lab manager needed to increase throughput for CounterCurrent Chromatography (CCC) purifications. After discussions with PDR-Separations the company decided to have PDR-Separations reconfigure the company’s Dynamic Extractions Spectrum dual CCC […]
DALP-Sugar- A QC lab supporting production of a food additives exhibiting optical activity and no chromophore inside a large manufacturing company
PROBLEM The QC lab was struggling to process samples fast enough and accurately enough using Refractive Index (RI) detection and production was increasing GOALS/SOLUTIONS The company’s QC lab manager needed to increase throughput and accuracy to support increasing production requirements After discussions with PDR-Separations the company decided to replace all RI detectors with PDR-Separations Advanced […]
DALP-SMB- A large pharmaceutical manufacturing company utilizing simulated moving bed (SMB) chromatography systems to purify enantiomers in large production batches
PROBLEM The SMB lab was struggling to process different batches quickly enough, largely due to extended method optimization time. The necessity to extracting and analyze multiple samples via HPLC meant enantiomeric purity results were delayed by an hour or more. GOALS/SOLUTIONS The SMB lab needed to reduce method optimization time. PDR-Separations Installed DALPs (digital advanced […]
Decon-SMB- A large pharmaceutical company manufacturing active pharmaceutical ingredients (API)
PROBLEM The company was having difficulty with isolating and purifying trace impurities in APIs for the identification and characterization required by regulatory agencies. GOALS/SOLUTIONS PDR-Separations was contracted to install a spectral deconvolution system on a pilot-scale SMB system. The customer wanted to isolate trace impurities in APIs for proper analysis and characterization along with making […]